This paper was communicated to the National Academy of Sciences of the United States of America by William E. Paul, the discoverer of Interleukin 4 the and recipient of the Max Delbr?ck Medal. This paper describes the molecular events responsible for activation of macrophages and how they relate to cancer immune-surveillance. This paper predates other observation on macrophage activation and cancer and constitutes one of the molecular bases underlying the Immortalis Protocol.
Pierce JH, Di Marco E, Cox G, Lombardi D, Di Fiore PP, Ruggiero M, Varesio L, Sakaguchi AY and Aaronson SA
Proc. Natl. Acad. Sci. USA 87: 5613-5617, 1990